Persistent concerns or physical symptoms such as headaches, digestive tract and chronic pain does not respond to routine and treatment. Major depression or depressive syndrome has occurred see the list of symptoms, which interfere with the ability to work, study, sleep, eat and enjoy a nice time activities. Research and clinical evidence that women and men can develop the standard symptoms of depression, depression is often different and may have different ways of coping with the symptoms. Trouble sleep, early morning awakening, or oversleeping.