Deficiencies in biotin, B vitamins,, depression prozac, folic acid, B6 and B12 associated with depression, such as vitamin C deficiencies. Depression is a risk factor for coronary heart disease. Some of the symptoms of menopause are also symptoms of depression, so it is important to look at the whole picture. Depression may increase the risk of heart disease in patients with coronary artery disease. This is because the nerve fibers are coated with a layer of fat called myelin.