GERD is caused by a weakening of symptoms of acid reflux in women the valve that connects the esophagus and stomach, called the lower esophageal sphincter, or LES. Sadly, though, Reglan can also cause some severe side effects that have permanent repercussions. While heartburn is often prevented by avoiding gastrological extravagance or certain “trigger foods”, some people can suffer from chronic attacks of heartburn for no apparent reason.